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KMID : 0382619840040010169
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Hanyang Journal of Medicine
1984 Volume.4 No. 1 p.169 ~ p.185
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A Study of Transferability of Drug Resistance of Escherichia coli
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朴聖洙/Park, Sung Soo
趙陽子/徐仁銖/Cho, Yang Ja/Suh, Inn Soo
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Abstract
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Seven hundred and seventy one Escherichia coli strains were isolated in Seoul area during a period from 1982 to 1983. These strains were originated from facal specimens of 257 infantile diarrhea who had more than 3 times diarrhea per day. This study was made an attempt to assess the present state of serotypes, enterotoxin production, drug resistance and transferability of both conjugated R plasid and thermosensitive R plasmid.
Among 771 strains of Escherichia coli, 97.1% were unserotyped and 2.8% were serotyped, in which the commonest type was O126:K71. The only 1 strain of unserotyped Escherichia coli produced both heat-stable enterotoxin and heat-labile enterotoxin.
In unserotyped Escherichia coli, the incidence of strains resistant to AP, TC, CM, KM SM and CER were 42.6%, 37.1%, 29.4%, 23.6%, 16.4% and 6.8% in decreasing order of frequency and in serotyped Escherichia coli, the incidence of strains resistant to AP, TC, KM, CM, SM and CER were 90.9%, 86.4%, 81.8%, 77.3%, 31.8% and 9.1% respectively.
Among unserotyped and serotyped Escherichia coli, 20.6% were foundto be resistant to two or more drugs tested and the most common pattern was KM. AP. CM. TC(27%). In the detection of R plasmid in Escherichia coli, the most common R plasmid was R(AP) 68.3% and in serotyped Escherichia coli R(KM)72.2%, in unserotyped Escherichia coli R(AP) 71.3%, respectively.
Twenty two kinds of R plasmids were demonstrated in Escherichia coli, among which the most common transmissible R plasmid was R(AP). In tne detection of thermosensitive R plasmid transferring ampicillin resistance from Escherichia coli strains in serotyped and unserotyped, all strains transferred only at 25℃
The frequency of R plasmid in serotyped Escherichia coli strains was 100%, in which incidence of strains of resistance transferred was 90% partially and 10% completely.
Among unserotyped Escherichia coli, non-enterotoxigenic Escherichia coli transferring partial resistance was 47.2% and one tansferring complete resistance was 22% and enterotoxigenic Escherichia coli transferred complete resistance.
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